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KMID : 0360319920240050702
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Journal of Korean Cancer Research Association
1992 Volume.24 No. 5 p.702 ~ p.707
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Treatment of Advanced Gastric Cancer with 5-Fluorouracil, Etoposide and Cisplatin(FEP)
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장정순
임영혁/윤성수/이재용/허대석/방영주/김노경
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Abstract
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We conducted a pase II trial of 5-fluoruracil(5-FU). etoposide(VP-16) and cisplatin in previously untreated patients with metastatic or recurrent gastric adenocarcinoma.
Thirty-six patients entered on study from December 1989 to July 1991. The treatment regimen consisted of a 12 hr continuous infusion of 5-FU(800mg/m*/day) for 5 consecutive days, a bolus iv of VP-16(70mg/m*/day) and cisplatin(25mg/m*/day) for a
consecutive days respectively. Treatment was repeated every 3 weeks.
Among 30 evaluable patients, 1 patient(3%) achieved a complete response and 9 patients(30%) partial responses, giving an overall response rate of 33%. The median duration of response was 4 months. The median survival for responders was 11 months.
Toxicities were common and included bone marrow suppression, nausea and vomiting, alopecia and peripheral neuropathy.
In conclusion, a combination chemotherapy with FEP regimen in patients with advanced gastric cancer seems to be comparable to other chemotherapy regimens in efficacy and toxicity.
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KEYWORD
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